GENERATION OF HYPOIMMUNOGENIC INDUCED PLURIPOTENT STEM CELLS BY CRISPR-CAS9 SYSTEM AND DETAILED EVALUATION FOR CLINICAL APPLICATION

Generation of hypoimmunogenic induced pluripotent stem cells by CRISPR-Cas9 system and detailed evaluation for clinical application

In order to expand the promise of regenerative medicine using allogeneic induced pluripotent stem cells (iPSCs), precise and efficient genome editing of human leukocyte antigen (HLA) genes would be advantageous to minimize the immune rejection caused by mismatches of HLA type.However, clinical-grade genome editing of multiple Ottoman HLA genes in h

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HCV microelimination in harm reduction centres has benefits beyond HCV cure but is hampered by high reinfection rates

Background & Aims: Significant scale-up of treatment among people who inject drugs (PWID) is crucial to achieve WHO HCV elimination targets.We explored the impact of on-site HCV diagnosis and treatment on PWID in an externalised hepatology clinic at the biggest harm reduction centre (HRC) in Barcelona attending to a marginalised PWID population

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Integrating ethics in AI development: a qualitative study

Abstract Background While the theoretical benefits and harms of Artificial Intelligence (AI) have been widely discussed in academic literature, empirical evidence remains elusive regarding the practical ethical challenges of developing AI for healthcare.Bridging the gap between theory and practice is an essential step in understanding how to ethica

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The Influence of Interesterification on the Thermal and Technological Properties of Milkfat-Rapeseed Oil Mixture and Its Potential Use in Incorporation of Model Meat Batters

Enzymatic interesterification gives the possibility to obtain a wide range of lipids with a modified structure.In the present study, model meat batters were produced from chicken breast muscles and enzymatically interesterified fats: milkfat:rapeseed oil (3:2 w/w).Fatty acids composition and their positional distribution in triacylglycerol, melting

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